Direct-current-based image reconstruction versus direct-current included or excluded frequency-domain reconstruction in diffuse optical tomography.

We study the level of image artifacts in optical tomography associated with measurement uncertainty under three reconstruction configurations, namely, by using only direct-current (DC), DC-excluded frequency-domain, and DC-included frequency-domain data. Analytic and synthetic studies demonstrate that, at the same level of measurement uncertainty typical to optical tomography, the ratio of the standard deviation of mu(a) over mu(a) reconstructed by DC only is at least 1.4 times lower than that by frequency-domain methods. The ratio of standard deviations of D (or mu(s)') over D (or mu(s)') reconstructed by DC only are slightly lower than those by frequency-domain methods. Frequency-domain reconstruction including DC generally outperforms that excluding DC, but as the amount of measurements increases, the difference between the two diminishes. Under the condition of a priori structural information, the performances of three reconstruction configurations are seemingly equivalent.